m-PEG8-DBCO
This product is a monofunctional PEG8 linker terminated with a dibenzocyclooctyne (DBCO) group. The PEG8 spacer provides hydrophilicity and flexibility, while the DBCO enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC), making it ideal for bioorthogonal conjugation, drug delivery, and surface functionalization.
Key Features and Benefits:
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DBCO Group: Supports copper-free click chemistry with azides under mild conditions.
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PEG8 Spacer: Offers solubility, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Copper-Free Reactivity: Compatible with live-cell and in vivo labeling.
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Medium Chain Length: PEG8 provides balance between solubility and spacing.
Applications:
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Click Chemistry: SPAAC ligation for biomolecule and polymer modification.
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Bioconjugation: Enables selective labeling of proteins, peptides, and antibodies.
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Drug Delivery: Useful for linker–payload systems in targeted therapeutics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and biosensors.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain DBCO reactivity.
This product combines medium-length PEG spacing with copper-free click functionality, making it an especially versatile reagent for bioconjugation and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
