m-PEG3-Sulfone-PEG3-t-butyl ester
This product is a high-purity heterobifunctional PEG linker featuring a methyl-terminated PEG3 chain, a sulfone moiety for thiol-based conjugation, and a t-butyl ester-protected carboxylic acid. The PEG3 spacers enhance water solubility, reduce steric hindrance, and provide flexibility for controlled, orthogonal bioconjugation strategies.
Key Features and Benefits
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Sulfone Group: Reacts selectively with thiols to form stable thioether bonds.
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t-Butyl Ester-Protected Carboxylic Acid: Stable under neutral/basic conditions; deprotect under mild acidic conditions to reveal a reactive acid.
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Dual PEG3 Spacers: Improve solubility and accessibility of functional groups.
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Methyl-Terminated End: Minimizes nonspecific interactions and provides hydrophilic balance.
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High Purity: >95% purity ensures reproducible and reliable results.
Applications
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Stepwise and orthogonal bioconjugation.
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Protein, peptide, and antibody modification.
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Drug delivery system design with cleavable linkers.
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Nanoparticle and surface functionalization.
Storage and Handling
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Storage: Store at –20 °C, dry, protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture.
A heterobifunctional PEG linker with sulfone and protected acid functionalities for sequential, thiol-specific and acid-activated conjugations in biomolecular and materials applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
