m-PEG3-NHS Ester
m-PEG3-NHS Ester is a PEG-based linker featuring a triethylene glycol (PEG3) spacer and a reactive NHS ester group. As a result, it reacts efficiently with primary amines under mild, aqueous conditions. Consequently, it is widely used for site-specific PEGylation of proteins, peptides, antibodies, and surfaces.
Moreover, the PEG3 chain enhances solubility and reduces steric hindrance, allowing for flexible and reliable conjugation. Due to its excellent biocompatibility, this reagent is well-suited for a variety of research and clinical applications.
Key Features and Benefits:
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Efficient Amine-Reactive Chemistry: NHS ester rapidly couples to primary amines under mild conditions.
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PEG3 Spacer: Provides flexible, hydrophilic linkage that reduces steric hindrance and improves solubility.
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Monodisperse Structure: Ensures consistent performance and reproducible conjugation.
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Versatile Conjugation: Ideal for PEGylation of proteins, peptides, nanoparticles, and small molecules.
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Biocompatible: Non-toxic and hydrophilic for improved pharmacokinetics and reduced immunogenicity.
Applications:
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Protein and Peptide PEGylation: Enhances solubility, stability, and circulation half-life of biomolecules.
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Antibody and Enzyme Conjugation: Site-selective modification for therapeutic and diagnostic use.
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Surface Functionalization: Coats nanoparticles, medical devices, or biosensors with PEG for reduced nonspecific binding.
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Drug Delivery: Improves solubility and targeting of drug carriers.
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Immunoassays and Diagnostics: Enables labeling of biomolecules for enhanced detection.
Storage and Handling:
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Storage: Store at -20°C, protected from light and moisture.
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Handling: Use anhydrous solvents. NHS ester is moisture-sensitive—prepare fresh solutions before use.
m-PEG3-NHS Ester offers reliable PEGylation performance with a short, flexible spacer arm, making it ideal for both research and development in bioconjugation, targeted delivery, and advanced diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
