Hydroxy-PEG3-methylamine
This product is a heterobifunctional PEG linker containing a terminal hydroxyl group, a three-unit PEG spacer, and a primary methylamine group. The hydroxyl group provides a versatile handle for derivatization, while the amine couples efficiently with carboxyls or activated esters to form stable amide bonds. The PEG3 spacer specifically enhances solubility and reduces steric hindrance, making this reagent a compact and flexible intermediate for bioconjugation.
Key Features and Benefits
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Hydroxyl Group: Provides a modifiable handle for further chemical functionalization.
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Methylamine Group: Couples with carboxyls or NHS esters to form amide bonds.
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PEG3 Spacer: Adds solubility, flexibility, and moderate spacing.
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Dual Reactivity: Supports versatile conjugation strategies.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links hydroxyl- and carboxyl-reactive molecules.
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Protein and Antibody Labeling: Provides dual handles for controlled modification.
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Probe Development: Serves as a building block for multifunctional probes.
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Drug Delivery: Functions as a compact linker in therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product integrates hydroxyl and amine reactivity in a short PEG3 scaffold, making it an especially versatile tool for conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
