HO-PEG13-t-butyl ester
This PEG13 linker has a hydroxyl group and a t-butyl ester as an acid-labile protection. The long PEG13 chain provides hydrophilicity, flexibility, and spacing, while the ester enables controlled deprotection for orthogonal conjugation.
Key Features and Benefits:
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Hydroxyl Group: Provides a versatile handle for further derivatization.
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t-Butyl Ester: Acid-labile protection enabling controlled carboxyl release.
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PEG13 Spacer: Ensures long hydrophilic spacing, solubility, and reduced steric hindrance.
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High Purity: Delivers reproducibility in synthetic and bioconjugation workflows.
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Orthogonal Reactivity: Supports stepwise conjugation and multifunctional applications.
Applications:
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Bioconjugation: Enables dual-functional modification with controlled ester deprotection.
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Drug Delivery: PEGylated scaffold improves solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels.
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Synthetic Chemistry: Acts as an intermediate for advanced PEG-based scaffold design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve hydroxyl and ester stability.
This product combines hydroxyl versatility with acid-labile protection in a long PEG chain, making it an especially powerful tool for conjugation, controlled release, and scaffold synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
