HO-PEG5-t-butyl ester
HO-PEG5-t-butyl ester is a high-purity monofunctional PEG derivative featuring a terminal hydroxyl group and a t-butyl ester-protected carboxylic acid. The PEG5 spacer enhances hydrophilicity, improves solubility, and reduces steric hindrance, enabling especially efficient coupling in both aqueous and organic systems. The t-butyl ester group offers acid-labile protection, allowing selective deprotection under mild acidic conditions to yield the free carboxylic acid for further conjugation.
Key Features
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Terminal hydroxyl group for further functionalization
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t-Butyl ester protection enables controlled release of carboxylic acid under mild acidic conditions
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PEG5 spacer improves water solubility and reduces aggregation
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High chemical stability and purity
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Suitable for both aqueous and organic phase synthesis
Applications
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Synthesis of PEGylated biomolecules, polymers, and small molecules
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Controlled carboxyl deprotection for stepwise conjugation
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Spacer in drug delivery and bioconjugation workflows
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Intermediate for multifunctional linker preparation
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product contains a terminal hydroxyl group for functionalization and a t-butyl ester-protected acid for controlled deprotection, with a PEG5 spacer specifically to enhance solubility and reduce steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
