H3-K27me3
This product refers to the trimethylation of lysine 27 on histone H3, a well-characterized epigenetic modification that plays a central role in transcriptional regulation and chromatin organization. This repressive histone mark is deposited by the polycomb repressive complex 2 (PRC2) through its catalytic subunit EZH2 and is associated with gene silencing and stable epigenetic memory. H3-K27me3 is especially studied in developmental biology, stem cell differentiation, and cancer epigenetics.
Key Features and Benefits
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Epigenetic Mark: Represents a transcriptionally repressive histone modification.
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Catalyzed by PRC2: Specifically deposited by EZH2, EED, and SUZ12 complex activity.
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Stable Regulation: Maintains long-term silencing of developmental and lineage-specific genes.
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Disease Relevance: Dysregulation linked to oncogenesis, particularly in lymphomas and solid tumors.
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Research Utility: Serves as a biomarker for chromatin state and transcriptional repression.
Applications
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Epigenetics Research: Tracks chromatin repression in development and differentiation.
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Cancer Biology: Investigates oncogenic pathways and therapeutic targeting of EZH2.
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Stem Cell Studies: Explores lineage commitment and pluripotency regulation.
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Diagnostics and Biomarkers: Monitors chromatin states in disease progression.
Storage and Handling (for reagents/antibodies specific to H3-K27me3)
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Storage: Store antibodies or detection reagents at –20 °C or according to manufacturer instructions.
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Handling: Avoid repeated freeze–thaw cycles; prepare aliquots for consistent use.
This product is a central histone modification that integrates chromatin regulation with developmental control and disease pathways, making it an especially critical focus in modern epigenetics research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.