Gly-PEG3-endo-BCN
This product is a bifunctional linker containing a glycine residue, a PEG3 spacer, and an endo-bicyclononyne (BCN) handle. The PEG3 unit enhances solubility and flexibility, while the strained BCN enables rapid copper-free click chemistry with azides.
Key Features and Benefits
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Endo-BCN Group: Provides ultrafast, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides.
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Glycine Moiety: Adds biocompatibility and allows integration into peptide or protein conjugates.
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PEG3 Spacer: Improves solubility and reduces steric hindrance in bioconjugation workflows.
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Bioorthogonal Reactivity: Enables selective conjugation in complex biological environments.
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High Purity: Produced to ≥95% purity for reproducibility in research and development.
Applications
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Bioconjugation: Couples azide-containing biomolecules, drugs, or probes through SPAAC chemistry.
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Probe Development: Builds BCN-functionalized probes for imaging, diagnostics, and therapeutic studies.
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Drug Delivery: Supports design of bioorthogonal carriers and targeted delivery systems.
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Chemical Biology: Facilitates site-specific labeling of biomolecules in living systems.
Storage and Handling
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Storage: Keep at –20 °C in a tightly sealed container, protected from light and moisture.
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Handling: Use under inert atmosphere when possible; avoid prolonged heat exposure.
This product combines a biocompatible glycine unit, solubilizing PEG3 chain, and reactive BCN handle, making it an especially versatile tool for copper-free click chemistry and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
