Fmoc-PEG5-NHS ester
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine and an NHS ester, separated by a PEG5 spacer. It specifically enables amine protection, controlled conjugation, and versatile bioconjugation with improved solubility and flexibility.
Key Features and Benefits
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Dual Functional Groups: Fmoc-protected amine for controlled deprotection, NHS ester for efficient amine coupling.
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PEG5 Spacer: Provides solubility and spacing while reducing steric hindrance.
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High Efficiency: NHS ester reacts readily with primary and secondary amines.
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Versatile Linker: Supports stepwise synthesis, peptide modification, and protein conjugation.
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High Purity: Ensures reproducible results in research and synthesis workflows.
Applications
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Bioconjugation: Couples amine-containing biomolecules via the NHS ester.
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Peptide Synthesis: Fmoc group enables controlled, stepwise assembly.
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Drug Delivery: Provides PEG scaffolds for therapeutic conjugates.
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Diagnostics: Functionalizes biomolecules for probe and assay development.
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Organic Synthesis: Serves as a modular intermediate for advanced linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates an Fmoc-protected amine and an NHS ester across a PEG5 spacer, specifically providing flexibility, solubility, and orthogonal reactivity for bioconjugation and synthesis applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
