Fmoc-NH-PEG5-CH2COOH
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine, a PEG5 spacer, and a terminal carboxylic acid. It specifically enables orthogonal deprotection, amide coupling, and conjugation, offering solubility, medium flexibility, and versatile reactivity.
Key Features and Benefits
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Fmoc-Protected Amine: Provides orthogonal protection for staged deprotection and selective conjugation.
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Carboxylic Acid: Couples efficiently with primary amines to form stable amide bonds.
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PEG5 Spacer: Improves solubility and provides moderate chain length.
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Dual Reactivity: Combines protected amine functionality with carboxyl chemistry.
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High Purity: Ensures reproducibility in synthesis and conjugation workflows.
Applications
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Bioconjugation: Links PEG scaffolds to biomolecules with controlled reactivity.
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Probe Development: Builds multifunctional probes with orthogonal handles.
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Drug Delivery: Provides PEG scaffolds with solubility and dual handles.
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Organic Synthesis: Serves as an intermediate in linker and scaffold design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Fmoc cleavage.
This product integrates Fmoc-protected amine chemistry with carboxyl reactivity in a PEG5 scaffold, specifically offering solubility, flexibility, and multifunctional conjugation capability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
