Fmoc-NH-PEG4-CH2COOH
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine, a PEG4 spacer, and a terminal carboxymethyl group. The Fmoc group protects the amine for stepwise synthesis, while the carboxyl allows coupling to amines or activated esters. The PEG4 spacer improves solubility and flexibility, making this reagent especially useful for peptide synthesis, bioconjugation, and linker design.
Key Features and Benefits
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Fmoc-Protected Amine: Stable under synthesis conditions, removable with mild base.
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Carboxymethyl Group: Couples efficiently with amines to form amide bonds.
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PEG4 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
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Orthogonal Reactivity: Supports stepwise protection and deprotection strategies.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Peptide Synthesis: Introduces PEG spacers into peptides via SPPS.
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Bioconjugation: Links proteins, peptides, or probes through amine and acid chemistry.
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Drug Delivery: Serves as a modular linker for PEGylated therapeutics.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture-free container.
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Handling: Deprotect Fmoc under standard SPPS conditions; prepare fresh solutions when needed.
This product combines orthogonally protected amine chemistry with a carboxymethyl handle and PEG4 solubility, specifically offering a versatile tool for synthesis and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
