Fmoc-Ala-Ala-Asn(Trt)-PAB
This high-purity peptide–PAB linker has a sequence for protease-triggered cleavage and a PAB spacer for rapid payload release, especially ideal for targeted drug delivery and ADCs.
Key Features and Benefits
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Fmoc Protection – Ensures stability during solid-phase peptide synthesis (SPPS) and allows selective deprotection.
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Ala-Ala-Asn(Trt) Sequence – Cleavable by specific proteases for controlled payload release.
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PAB Spacer – Undergoes rapid 1,6-elimination after enzymatic cleavage for efficient payload liberation.
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High Purity – Supplied at >95% purity for reproducible results in sensitive applications.
Applications
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ADC linker design for targeted cancer therapeutics
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Controlled drug release systems
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Enzyme-responsive prodrug development
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Peptide-based targeting and delivery research
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents; avoid prolonged moisture exposure to maintain reactivity.
This product is a protease-cleavable peptide linker with a PAB spacer for efficient payload release in targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
