Fmoc-Ala-Ala-Asn(Trt)-OH
CAS: 1951424-92-2
Description:
Fmoc-Ala-Ala-Asn(Trt)-OH is a protected tripeptide used in peptide synthesis, particularly valued for its role as a cathepsin B cleavable linker. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the N-terminus, while the Trt (trityl) group protects the side chain of asparagine, making it suitable for solid-phase peptide synthesis (SPPS) and applications in drug delivery.
Key Features:
- Fmoc Protection: Temporarily shields the N-terminal amine, allowing for controlled, sequential peptide synthesis.
- Trt Protection on Asn: Prevents side reactions by protecting the asparagine side chain during synthesis.
- Cathepsin B Cleavable Linker (Ala-Ala-Asn): Enables specific cleavage by cathepsin B, commonly used in drug delivery systems for targeted release within tumor cells.
- Peptide Prodrug Applications: Often used in peptide prodrugs for controlled release within specific cellular environments, such as tumor cells.
Applications:
- Solid-Phase Peptide Synthesis (SPPS): Useful in constructing complex peptides, especially those needed for research and pharmaceuticals.
- Targeted Drug Delivery: Acts as a cathepsin B cleavable linker, allowing controlled release of drugs in specific cellular environments, such as in cancer therapy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
