Ethyl 2-methylcycloprop-2-ene-1-carboxylate
This product is a small, strained-ring ester featuring a cyclopropene core with a carboxylate ester substituent. The highly strained cyclopropene double bond serves as a reactive handle for bioorthogonal reactions such as inverse electron-demand Diels–Alder (IEDDA) ligations with tetrazines, while the ethyl ester provides stability and synthetic flexibility.
Key Features and Benefits
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Cyclopropene Core: Highly strained double bond for rapid IEDDA ligations.
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Ethyl Ester Group: Provides stability and a handle for further derivatization.
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Compact Structure: Minimal steric bulk for efficient incorporation.
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Versatile Chemistry: Useful for probe development, polymer design, and click applications.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioorthogonal Chemistry: Enables fast tetrazine ligation in labeling studies.
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Probe Development: Serves as a reactive building block for imaging agents.
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Polymer and Material Science: Introduces strained alkene reactivity into functional materials.
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Synthetic Intermediate: Precursor for functionalized derivatives in medicinal chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, protected from light and moisture.
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Handling: Use under inert conditions; prepare fresh solutions before use.
This product combines cyclopropene reactivity with ester stability, making it an especially valuable intermediate for click chemistry, probe design, and material modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
