BCN-PEG4-PNP

BCN-PEG4-PNP

This product is a PEG4 linker featuring a bicyclo[6.1.0]nonyne (BCN) group for copper-free SPAAC click chemistry and a para-nitrophenyl (PNP) ester for amine coupling. The PEG4 spacer adds solubility, flexibility, and moderate spacing, making it especially valuable for dual-functional bioconjugation and probe design.

Key Features and Benefits:

• BCN Group: Enables copper-free SPAAC click chemistry with azides.

• PNP Ester: Couples rapidly with amines to form stable amide bonds.

• PEG4 Spacer: Provides hydrophilicity, reduced steric hindrance, and balanced chain length.

• Dual Reactivity: Supports orthogonal conjugation in one or two-step strategies.

• High Purity: Ensures reproducibility in sensitive bioconjugation workflows.

Applications:

• Bioconjugation: Links biomolecules through amine coupling and click chemistry.

• Click Chemistry: Supports efficient azide–alkyne ligation without copper catalysts.

• Probe Development: Builds multifunctional probes for imaging and diagnostic use.

• Drug Delivery: PEGylated linker enhances solubility, stability, and pharmacokinetics.

Storage and Handling:

• Storage: Store at –20 °C in a sealed, moisture-free, light-protected container.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve PNP ester stability.

This product combines copper-free click reactivity with efficient amine coupling in a compact PEG framework, making it an especially versatile tool for advanced conjugation and therapeutic research.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.