endo-BCN-PEG4-PFP ester
This product is a heterobifunctional PEG linker containing an endo-bicyclo[6.1.0]nonyne (BCN) group, a PEG4 spacer, and a pentafluorophenyl (PFP) ester. It enables copper-free click chemistry and amine coupling, specifically offering high reactivity and solubility in a compact scaffold.
Key Features and Benefits
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Endo-BCN Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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PFP Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG4 Spacer: Improves solubility and provides moderate chain length.
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Dual Reactivity: Combines copper-free click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links azide-modified molecules with amine-containing partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with click and amine-reactive handles.
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Material Science: Functionalizes nanoparticles, surfaces, and polymers with dual reactivity.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates bioorthogonal BCN reactivity with amine-reactive PFP ester chemistry in a PEG4 scaffold, specifically offering versatile conjugation for bioconjugation and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
