endo-BCN-PEG4-NHS ester
endo-BCN-PEG4-NHS ester is a high-purity linker with an endo-bicyclononyne (BCN) group for copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) and an NHS ester for especially efficient amide bond formation with primary amines. The PEG4 spacer enhances solubility, flexibility, and reduces steric hindrance for optimal bioconjugation.
Key Features and Benefits
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Endo-BCN Group – Enables rapid, copper-free SPAAC click chemistry with azides
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NHS Ester – Reacts efficiently with primary amines for stable amide bond formation
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PEG4 Spacer – Improves solubility, flexibility, and accessibility of reactive sites
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Orthogonal Reactivity – Allows sequential and site-specific modifications
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High Purity – >95% for consistent and reproducible performance
Applications
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Dual-functional linker for orthogonal bioconjugation
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Protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) development
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Biomaterials and hydrogel functionalization
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Multifunctional probe and biosensor synthesis
Storage and Handling
- Storage: Store at –20 °C, dry, and protected from light
- Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture
This product combines BCN for copper-free SPAAC click chemistry and NHS ester for amine coupling, separated by a PEG4 spacer for solubility and flexibility, enabling especially efficient orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
