EGS Crosslinker
This product is a homobifunctional, non-cleavable, amine-reactive crosslinker featuring two NHS ester groups separated by a hydrophilic spacer. It efficiently forms stable amide bonds, making it especially valuable for protein crosslinking, structural biology, and bioconjugation studies.
Key Features and Benefits:
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Dual NHS Esters: React with primary amines under mild conditions.
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Hydrophilic Spacer: Reduces steric hindrance and preserves biomolecular function.
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Non-Cleavable Linker: Provides permanent, stable amide bonds.
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Versatile Use: Compatible with aqueous buffers at physiological pH.
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High Purity: Ensures reproducible and reliable results.
Applications:
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Protein Crosslinking: Stabilizes protein–protein interactions for structural analysis.
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Bioconjugation: Links enzymes, antibodies, and other amine-containing biomolecules.
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Structural Biology: Supports crosslinking mass spectrometry (XL-MS) workflows.
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Material Science: Functionalizes polymers and biomaterials with stable amide bonds.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Reconstitute in anhydrous DMSO or DMF; prepare fresh solutions before use.
This product provides efficient amine-reactive chemistry with a hydrophilic spacer, specifically enabling permanent crosslinks in protein analysis, structural biology, and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
