DSPE-Polysarcosine-Mal, DP 25 is a maleimide-functionalized lipid-polymer conjugate featuring a hydrophobic DSPE lipid anchor and hydrophilic polysarcosine chain. The polysarcosine segment has approximately 25 repeat units, while the terminal maleimide supports thiol-selective bioconjugation and lipid functionalization.
Key Features and Benefits
- Amphiphilic Structure: DSPE-Polysarcosine-Mal combines a hydrophobic phospholipid anchor with a hydrophilic polysarcosine chain.
- Polysarcosine DP 25: The polymer segment contains approximately 25 sarcosine repeat units, providing a compact hydrophilic spacer.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into lipid membranes and assemblies.
- Maleimide Functionality: The terminal maleimide provides a reactive site for conjugation with sulfhydryl-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with thiol groups under suitable conditions.
- Stable Conjugation: Maleimide-thiol coupling forms a stable thioether linkage for functional conjugate development.
- Hydrophilic Polymer Spacer: Polysarcosine provides hydrophilic separation between the DSPE anchor and reactive maleimide functionality.
- Functional Lipid-Polymer Platform: DSPE, polysarcosine, and maleimide functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Thiol Conjugation: DSPE-Polysarcosine-Mal, DP 25 supports conjugation with thiol- and cysteine-containing molecules.
- Bioconjugation: The terminal maleimide enables attachment of compatible peptides, proteins, ligands, and other thiolated molecules.
- Lipid Nanoparticle Research: Supports incorporation of maleimide-functionalized polysarcosine into experimental lipid nanoparticle systems.
- Liposome Research: Enables functionalization of liposomes and related lipid assemblies with hydrophilic polysarcosine chains.
- Ligand Conjugation: Supports attachment of thiol-containing ligands through maleimide-thiol chemistry.
- Nanoparticle Functionalization: Provides a thiol-reactive polymer terminus specifically for modification of compatible nanoparticle systems.
- Surface Modification: Supports presentation of hydrophilic polysarcosine chains and reactive maleimide groups on compatible surfaces.
- Biomaterial Research: Enables development of functional lipid-polymer materials for conjugation and biomaterial studies.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
DSPE-Polysarcosine-Mal, DP 25 combines a DSPE lipid anchor, compact polysarcosine chain, and thiol-reactive terminal maleimide and specifically supports bioconjugation, ligand attachment, lipid formulation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.