DSG-PEG-Maleimide, MW 2K is a thiol-reactive lipid-PEG conjugate containing a hydrophobic distearoyl glycerol (DSG) anchor and hydrophilic 2K PEG spacer, while its terminal maleimide group supports selective thiol conjugation for bioconjugation, ligand attachment, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSG-PEG-Maleimide combines a hydrophobic DSG lipid anchor with a hydrophilic PEG chain.
- PEG MW 2K: The 2K PEG spacer provides hydrophilic character and separates the reactive maleimide from the lipid anchor.
- DSG Lipid Anchor: The distearoyl glycerol group specifically supports incorporation into lipid-based assemblies and hydrophobic environments.
- Maleimide Functionality: The terminal maleimide provides a reactive site for conjugation with thiol-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with sulfhydryl groups under suitable conditions.
- Stable Conjugation: Maleimide-thiol coupling forms a stable thioether linkage specifically for functional conjugate development.
- PEG Spacer: The PEG chain provides separation between the DSG anchor and terminal maleimide functionality.
- Functional Lipid Platform: DSG, PEG, and maleimide functionality specifically support modification of lipid and nanomaterial systems.
Applications
- Thiol Conjugation: Researchers use DSG-PEG-Maleimide, MW 2K to conjugate compatible thiol-containing molecules.
- Bioconjugation: Supports coupling with cysteine-containing peptides, proteins, and other sulfhydryl-functionalized molecules.
- Lipid Nanoparticle Research: Enables surface functionalization of lipid-based nanoparticles with thiol-containing ligands.
- Liposome Research: Supports incorporation of PEG and maleimide functionality into liposomal research systems.
- Ligand Conjugation: The terminal maleimide enables attachment of compatible thiol-functionalized ligands.
- Nanoparticle Functionalization: Supports surface modification of compatible nanoparticle and nanomaterial systems.
- Surface Modification: Provides a thiol-reactive PEG linker for functional surface engineering.
- Biomaterial Research: Supports development of functional lipid-PEG materials and thiol-reactive conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
DSG-PEG-Maleimide, MW 2K combines a DSG lipid anchor, hydrophilic PEG spacer, and thiol-reactive maleimide group and specifically supports bioconjugation, ligand attachment, lipid nanoparticle functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.