DSG-PEG-Azide, MW 2K is an azide-functionalized lipid-PEG conjugate containing a hydrophobic distearoyl glycerol (DSG) anchor and hydrophilic 2K PEG spacer, while its terminal azide supports click chemistry for bioconjugation, ligand attachment, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSG-PEG-Azide combines a hydrophobic DSG lipid anchor with a hydrophilic PEG chain.
- PEG MW 2K: The 2K PEG spacer provides hydrophilic character and separates the reactive azide from the lipid anchor.
- DSG Lipid Anchor: The distearoyl glycerol group specifically supports incorporation into lipid-based assemblies and hydrophobic environments.
- Azide Functionality: The terminal azide provides a versatile reactive group for bioorthogonal click chemistry.
- CuAAC Click Chemistry: The azide reacts with terminal alkynes specifically through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azide reacts with strained cyclooctynes, such as DBCO, without requiring a copper catalyst.
- Bioconjugation Capability: Click chemistry supports attachment of compatible peptides, proteins, ligands, polymers, and other functional molecules.
- Functional Lipid Platform: The combination of DSG, PEG, and azide specifically upports functionalization of lipid and nanomaterial systems.
Applications
- Click Chemistry: Researchers use DSG-PEG-Azide, MW 2K for CuAAC and SPAAC conjugation reactions.
- Bioconjugation: Supports attachment of alkyne- or cyclooctyne-functionalized biomolecules and research ligands.
- Lipid Nanoparticle Research: Enables functionalization of lipid-based nanoparticles with compatible click-reactive molecules.
- Liposome Research: Supports incorporation of PEG and azide functionality into liposomal research systems.
- Ligand Conjugation: The terminal azide enables attachment of compatible targeting ligands and functional molecules.
- Nanoparticle Functionalization: Supports surface modification of compatible nanoparticle and nanomaterial systems.
- Surface Modification: Provides a click-reactive PEG linker for functional surface engineering.
- Biomaterial Research: Supports development of functional lipid-PEG materials and bioorthogonal conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSG-PEG-Azide, MW 2K combines a DSG lipid anchor, hydrophilic PEG spacer, and click-reactive azide group that specifically supports CuAAC, SPAAC, bioconjugation, lipid nanoparticle functionalization, ligand attachment, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.