DOTA-(t-Butyl)3-PEG5-azide contains DOTA-(t-butyl) and azide moieties. DOTA is used as a chelating agent for cations. It has wide applications in tissue imaging, cancer diagnosis and treatment. The t-Butyl groups can be removed under acidic conditions to afford a free carboxylic acid. The azide group readily reacts with alkynes, DBCO and BCN via click chemistry to from triazole linkage. The PEG spacer can increase the solubility of compounds in aqueous media.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.