DOTA-PEG5-amine HCl salt
DOTA-PEG5-amine HCl salt is a chelator–linker with a DOTA unit, PEG5 spacer, and terminal amine. It coordinates diagnostic or therapeutic radiometals, improves solubility, and specifically enables easy coupling for radiolabeling, probe development, and bioconjugation.
Key Features and Benefits
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DOTA Chelator: Forms stable complexes with radiometals such as ^64Cu, ^68Ga, ^111In, and ^177Lu.
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PEG5 Spacer: Provides solubility, flexibility, and spacing to improve conjugation efficiency.
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Amine Group (HCl Salt): Reacts readily with activated carboxylic acids and esters for functionalization.
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Biocompatible Design: Suitable for in vivo imaging, radiotherapy, and diagnostic probe development.
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High Purity: Manufactured to ≥95% purity for reliable and reproducible applications.
Applications
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Radiolabeling: Chelates diagnostic and therapeutic radionuclides for PET, SPECT, and radiotherapy.
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Bioconjugation: Couples readily to activated carboxyl or NHS esters for protein or small-molecule labeling.
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Probe Development: Builds radiolabeled probes for imaging and theranostics.
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Drug Delivery: Serves as a linker for targeted drug delivery systems with radionuclide tracking.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Dissolve freshly in aqueous buffer or dry solvent; avoid repeated freeze–thaw cycles.
This product integrates a DOTA chelator, PEG5 solubilizing spacer, and reactive amine terminus, specifically providing a versatile platform for radiolabeling, bioconjugation, and targeted therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.