DOPE-PEG-COOH, MW 5K is a linear heterobifunctional PEGylation reagent containing unsaturated DOPE phospholipids and carboxylic acids. The lipid tail can be used to encapsulate hydrophobic drugs, while the PEG chain maintains its water solubility. The polymer can be used to prepare liposomes or other nanoparticles in pharmaceutical nanocarrier applications. It is commonly used for targeted drug delivery, lipid bilayers can improve drug solubility, PEG can provide stealth properties, prolong circulatory half-life and reduce non-specific protein binding or cell adhesion, and amine groups can be used to bioconjugate targeting molecules including Antibodies, aptamers, proteins and peptides.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.