DMT-2′Fluoro-dU Phosphoramidite (CAS: 146954-75-8): Overview and Applications
DMT-2′Fluoro-dU Phosphoramidite (CAS: 146954-75-8) is a modified nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protective group and a 2′-fluoro substitution on deoxyuridine (dU), enhancing stability and functionality.
Key Features:
- DMT Group: Protects the 5′ hydroxyl, enabling selective coupling.
- 2′-Fluoro Substitution: Increases stability against nucleases and improves hybridization.
- Deoxyuridine Base: Maintains essential features while enhancing stability.
Applications:
- Oligonucleotide Synthesis: Ideal for creating stable DNA or RNA sequences.
- Gene Expression Studies: Used in probes and primers for nucleic acid analysis.
- Antisense Oligonucleotides: Enhances stability for therapeutic use.
- Diagnostics: Aids in developing DNA and RNA-based assays.
DMT-2′Fluoro-dU Phosphoramidite is crucial for synthesizing modified oligonucleotides in research and therapeutics.
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