Di(N-succinimidyl)adipate (DSA)

Di(N-succinimidyl)adipate (DSA)

This product is a homobifunctional NHS-ester crosslinker with two reactive succinimidyl ester groups linked by an adipate spacer. It reacts efficiently with primary amines, forming stable amide bonds, and is specifically used in protein crosslinking, conjugation, and material modification.

Key Features and Benefits:

• Dual NHS Esters: Enable efficient amine-to-amine crosslinking.

• Adipate Spacer: Provides moderate flexibility and spacing for conjugates.

• High Reactivity: Forms stable amide bonds under mild conditions.

• High Purity: Ensures reproducibility in protein chemistry and synthetic workflows.

• Versatile Crosslinker: Suitable for biomolecules, polymers, and surface chemistry.

Applications:

• Protein Crosslinking: Stabilize protein–protein or protein–ligand complexes.

• Bioconjugation: Couple peptides, antibodies, or other amine-containing molecules.

• Drug Delivery: Design linker systems with controlled spacing.

• Material Science: Modify surfaces, nanoparticles, or hydrogels with reactive amines.

Storage and Handling:

• Storage: Store at –20 °C in a dry, light-protected environment.

• Handling: Use freshly prepared anhydrous solvents (e.g., DMF, DMSO) to maintain NHS ester stability.

Di(N-succinimidyl)adipate is a versatile homobifunctional crosslinker that combines efficient NHS ester reactivity with an adipate spacer, making it an especially valuable tool in protein chemistry and advanced bioconjugation.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.