DBCO-TEG phosphoramidite, DBCO-PEG4-Phosphoramidite, CAS Number: 1527468-08-1
Overview:
DBCO-PEG4-Phosphoramidite is a powerful tool for click chemistry and oligonucleotide synthesis. It features a DBCO (dibenzylcyclooctyne) group, which reacts efficiently in strain-promoted azide-alkyne cycloaddition (SPAAC), allowing copper-free click reactions. The PEG4 (tetraethylene glycol) linker improves solubility and flexibility, ensuring better conjugation and reducing steric hindrance. This reagent is perfect for site-specific labeling of DNA/RNA and other bioconjugation tasks.
Applications:
- Oligonucleotide synthesis: Incorporates DBCO groups into DNA/RNA sequences.
- Click chemistry: Enables fast, copper-free conjugation with azide-modified molecules.
- Bioconjugation: Links proteins, peptides, and oligonucleotides with ease.
Benefits:
- Supports copper-free click chemistry, reducing toxicity and simplifying workflows.
- The PEG4 spacer enhances solubility and reduces steric hindrance for smoother reactions.
- Works well for a variety of bioconjugation and labeling applications.
Storage:
Store at -20°C, protected from light and moisture.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
