DBCO-PEG5-TFP Ester contains a DBCO and a TFP group. The active TFP ester is more stable than NHS ester and less prone to hydrolysis in aqueous meida and can be used to label amine bearing proteins, antibodies, and other biopolymers. The hydrophilic polyethylene glycol (PEG) spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to azide-containing molecules.
DBCO reagents are the most commonly used substrates for strain-promoted azide-alkyne click chemistry. DBCO compounds react with azide-tagged biomolecules quickly in high yield without using a Cu(I) catalyst or elevated temperature to result in a stable triazole linkage, making the DBCO bearing compounds perfect candidates for parrell synthesis.
DBCO-PEG5-TFP ester has been widely used in the development of drug conjugates for targeted drug delivery. By coupling the DBCO-PEG5-TFP ester with a targeting molecule (such as antibodies, peptides, or aptamers) through the click reaction, it can be selectively delivered to the disease site, reducing systemic toxicity and improving efficacy. The hydrolysis of the TFP ester group can also provide a site for conjugation with a therapeutic agent.
Moreover, DBCO-PEG5-TFP ester has been used to modify the surface of nanoparticles, enhancing their stability, and improving their circulation time. It can also be used to functionalize medical devices or implants, allowing for site-specific delivery and reducing the risk of immunogenicity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.