DBCO-PEG5-TFP Ester is a versatile bioconjugation reagent, combining a dibenzocyclooctyne (DBCO) group, a five-unit PEG spacer, and a stable tetrafluorophenyl (TFP) ester. This structure enables efficient copper-free click chemistry and amine-reactive labeling.
Key Features:
- DBCO Group: Allows strain-promoted azide-alkyne cycloaddition (SPAAC) without copper, ensuring compatibility with sensitive biomolecules.
- PEG5 Spacer: Enhances solubility and reduces steric hindrance, improving conjugation efficiency.
- TFP Ester: More hydrolysis-resistant than NHS esters, offering efficient and stable labeling of biopolymers.
Applications:
- Protein and Antibody Labeling: Modifies proteins, antibodies, and other amine-containing biomolecules for research and diagnostics.
- Bioconjugation: Enables the development of antibody-drug conjugates and targeted therapeutics by coupling with azide-functionalized molecules.
- Surface Functionalization: Attaches biomolecules to surfaces, supporting biosensor development and diagnostic tools.
- Medical Device Functionalization: Functionalizes medical devices or implants for site-specific delivery, reducing immunogenicity risk.
Handling and Storage:
- Storage Conditions: Store at -20°C in a dry, light-protected environment.
- Handling Precautions: Use personal protective equipment and ensure proper ventilation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
