DBCO-PEG4-NH-Boc
This product is a multifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG4 spacer, and a Boc-protected amine. It specifically enables copper-free click chemistry with azides and orthogonal amine conjugation after Boc deprotection.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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Boc-Protected Amine: Provides orthogonal reactivity after selective deprotection.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with protected amine functionality.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine-containing partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with orthogonal and bioorthogonal handles.
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Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with orthogonal Boc-protected amine reactivity, specifically offering a versatile scaffold for staged and modular conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
