DBCO-PEG4-Maleimide (CAS: 1480516-75-3) is a bifunctional linker used in bioconjugation and antibody-drug conjugate (ADC) development. It features a DBCO group for copper-free click chemistry with azides and a maleimide group for specific thiol conjugation. Its four-unit PEG4 spacer adds flexibility and improves water solubility.
Key Features:
- Dual Reactivity: The maleimide forms stable thioether bonds with thiol groups, while the DBCO group supports copper-free click reactions with azides.
- Enhanced Solubility: The PEG4 spacer increases hydrophilicity, ensuring better solubility in aqueous buffers.
- Flexible Spacer: PEG4 reduces steric hindrance, enabling more efficient and versatile bioconjugation.
DBCO-PEG4-Maleimide Applications:
- Antibody-Drug Conjugates (ADCs): Attaches cytotoxic drugs to antibodies for targeted cancer treatment.
- Bioconjugation: Links peptides, proteins, and nucleic acids for research, diagnostics, and therapeutic development.
- Click Chemistry: Enables copper-free conjugation with azide-functionalized molecules in biocompatible conditions.
How to Use:
- Storage: Keep at -20°C, away from light and moisture, to maintain stability.
- Solubility: Dissolves in organic solvents like DMSO, DMF, and DCM for versatile use.
DBCO-PEG4-Maleimide simplifies bioconjugation by combining click chemistry and thiol-reactive functionalities with enhanced solubility and flexibility, making it essential for advanced biomolecular research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
