DBCO-PEG2-PFP ester
This product is a heterobifunctional linker containing a dibenzocyclooctyne (DBCO) group, a PEG2 spacer, and a terminal pentafluorophenyl (PFP) ester. The DBCO enables rapid, copper-free SPAAC click chemistry with azides, while the PFP ester reacts efficiently with primary amines to form stable amide bonds. The PEG2 spacer adds solubility and flexibility in a compact design, making this reagent especially useful for dual-functional bioconjugation.
Key Features and Benefits
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DBCO Group: Supports ultrafast, copper-free SPAAC click chemistry with azides.
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PFP Ester: Provides efficient amine coupling with reduced hydrolysis compared to NHS esters.
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PEG2 Spacer: Enhances solubility and minimizes steric hindrance while maintaining compact size.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine conjugation.
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High Purity: Produced to ≥95% purity for reproducible applications.
Applications
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Bioconjugation: Couples azide-functionalized and amine-containing biomolecules.
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Protein and Antibody Labeling: Enables dual-site modifications for multifunctional constructs.
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Probe Development: Builds imaging and diagnostic probes with orthogonal reactivity.
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Drug Delivery: Serves as a PEGylated linker for targeted therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Prepare fresh solutions before use; avoid prolonged exposure to aqueous buffers.
This product combines copper-free click chemistry with stable amine-reactive functionality in a compact PEG2 scaffold, specifically offering versatility for protein labeling, probe development, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
