DBCO-NH-Boc
This product is a bifunctional linker containing a dibenzocyclooctyne (DBCO) group and a Boc-protected amine. It specifically enables copper-free click chemistry with azides and orthogonal amine conjugation after Boc deprotection.
Key Features and Benefits
-
DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
-
Boc-Protected Amine: Provides orthogonal reactivity after selective deprotection.
-
Copper-Free Chemistry: Suitable for biological systems without cytotoxic catalysts.
-
Compact Design: Minimizes steric hindrance during conjugation.
-
High Purity: Ensures reproducibility in sensitive workflows.
Applications
-
Bioconjugation: Links azide-modified biomolecules with amine-containing partners.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Provides scaffolds with orthogonal and bioorthogonal handles.
-
Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates bioorthogonal DBCO reactivity with a Boc-protected amine, specifically offering a versatile scaffold for modular and staged conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.