DBCO-C3-alcohol
This product is a compact heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group, a three-carbon spacer, and a terminal hydroxyl group. The DBCO enables rapid, copper-free SPAAC click chemistry with azides, while the hydroxyl group serves as a versatile handle for further functionalization. The short C3 chain provides minimal spacing with good solubility, making this reagent especially suitable for compact bioconjugation strategies.
Key Features and Benefits
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DBCO Group: Performs ultrafast, copper-free SPAAC click chemistry with azides.
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Hydroxyl Group: Offers a modifiable handle for derivatization.
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C3 Spacer: Provides compact length and moderate flexibility.
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Dual Reactivity: Supports click chemistry and secondary modification.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links azide-modified molecules with hydroxyl-derived partners.
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Protein and Antibody Labeling: Adds bioorthogonal reactivity for functional studies.
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Probe Development: Builds compact probes for imaging and diagnostics.
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Drug Delivery: Functions as a short linker in therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines strain-promoted click reactivity with a hydroxyl handle in a compact scaffold, making it especially useful for efficient conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
