a-D-Mannopyranoside, tetraacetate-PEG2-bromide
This product is a high-purity glycosylated PEG linker designed for targeted bioconjugation and glycobiology applications. It contains an a-D-mannopyranoside sugar protected by four acetate groups, connected via a hydrophilic PEG2 spacer to a reactive bromide. The tetraacetate protection safeguards the sugar during synthesis, while the bromide group enables efficient alkylation or nucleophilic substitution. The PEG2 spacer improves solubility and flexibility, ensuring optimal presentation of the sugar for biological interactions.
Key Features and Benefits:
-
Mannose Targeting: a-D-Mannopyranoside specifically binds to mannose-recognizing lectins and receptors.
-
Tetraacetate Protection: Prevents premature sugar reactivity during multistep synthesis.
-
Bromide Reactivity: Supports alkylation and substitution with thiols, amines, or other nucleophiles.
-
PEG2 Spacer: Enhances water solubility and reduces steric hindrance for better conjugation efficiency.
-
High Purity: Supplied at >95% purity for reliable performance in research and manufacturing.
Applications:
-
Glycobiology Research: Study carbohydrate–protein and mannose–receptor interactions.
-
Bioconjugation: Attach mannose units to biomolecules, nanoparticles, or surfaces.
-
Targeted Drug Delivery: Functionalize carriers for mannose receptor-mediated uptake.
-
Diagnostics: Develop mannose-modified biosensors and imaging agents.
-
Polymer and Hydrogel Functionalization: Introduce mannose motifs into biomaterials.
Storage and Handling:
-
Storage: Store at –20 °C in a dry, dark environment.
-
Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to maintain bromide reactivity and acetate integrity.
a-D-Mannopyranoside, tetraacetate-PEG2-bromide is a high-purity mannose-based PEG linker featuring tetraacetate-protected a-D-mannopyranoside, a PEG2 spacer for solubility and flexibility, and a reactive bromide group for efficient conjugation. It is ideal for glycobiology research, targeted drug delivery, bioconjugation, and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
