D-Biotin-PEG6-Thalidomide
This product is a multifunctional linker combining D-biotin for high-affinity avidin/streptavidin binding with thalidomide for cereblon (CRBN) recruitment. The PEG6 spacer enhances solubility and flexibility, making it especially valuable in PROTAC development, targeted degradation, probe design, and advanced drug delivery.
Key Features and Benefits:
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Biotin Moiety: Provides strong binding to avidin and streptavidin systems.
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Thalidomide Group: Engages CRBN, enabling targeted protein degradation.
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PEG6 Spacer: Improves solubility, spacing, and steric accessibility.
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Dual Functionality: Supports avidin capture and CRBN recruitment in one molecule.
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High Purity: Ensures reproducible results in advanced research.
Applications:
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PROTAC Development: Builds bifunctional degraders using CRBN and biotin handles.
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Probe Design: Creates multifunctional tools for mechanistic and imaging studies.
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Drug Delivery: Enhances solubility and circulation of conjugates.
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Bioconjugation: Combines biotin capture with targeted degradation.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light.
This product integrates biotin–avidin affinity with thalidomide-based CRBN binding, specifically offering a versatile scaffold for PROTACs, drug delivery, and multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.