Cholesterol-PEG-Vinyl Sulfone, MW 2K is an amphiphilic cholesterol-PEG conjugate containing a terminal vinyl sulfone group and specifically combines a hydrophobic cholesterol anchor with hydrophilic 2K PEG and thiol-reactive functionality for conjugation, membrane modification, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: Cholesterol-PEG-Vinyl Sulfone specifically combines hydrophobic cholesterol with hydrophilic PEG in one functional conjugate.
- PEG MW 2K: The 2K PEG segment provides a hydrophilic spacer between the cholesterol anchor and terminal vinyl sulfone.
- Cholesterol Anchor: The cholesterol moiety specifically supports association with lipid membranes, liposomes, and compatible lipid-based assemblies.
- Vinyl Sulfone Functionality: The terminal vinyl sulfone specifically provides a reactive site for conjugation with thiol-containing molecules.
- Thiol-Reactive Chemistry: Vinyl sulfone reacts with free thiols through Michael-type addition under suitable conditions.
- Stable Conjugation: Thiol addition to vinyl sulfone forms a stable thioether linkage specifically for functional conjugate development.
- PEG Spacer: The hydrophilic PEG chain separates the cholesterol anchor from the reactive terminal group.
- Functional Conjugation Platform: Combines membrane anchoring, PEG spacing, and thiol-reactive functionality within one material.
Applications
- Thiol Conjugation: Researchers use Cholesterol-PEG-Vinyl Sulfone, MW 2K to couple thiol-containing molecules through vinyl sulfone chemistry.
- Bioconjugation: Supports conjugation with cysteine-containing peptides, proteins, and other thiol-functionalized molecules.
- Liposome Functionalization: Enables introduction of thiol-reactive functionality into compatible liposome and lipid membrane systems.
- Nanoparticle Functionalization: Supports surface modification of lipid-based and compatible nanoparticle systems.
- Membrane Modification: The cholesterol anchor supports incorporation into compatible lipid membranes for subsequent functionalization.
- Ligand Conjugation: Enables attachment of thiol-containing ligands through the terminal vinyl sulfone group.
- Surface Modification: Provides a 2K PEG spacer and reactive vinyl sulfone for thiol-mediated surface functionalization.
- Biomaterial Research: Supports development of functional lipid assemblies, conjugates, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged exposure to thiol-containing reagents before intended conjugation. Allow the material to reach room temperature before opening to minimize condensation.
Cholesterol-PEG-Vinyl Sulfone, MW 2K combines a cholesterol anchor, hydrophilic PEG spacer, and thiol-reactive vinyl sulfone and specifically supports thiol conjugation, membrane modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
