Cholesterol‑PEG‑Vinyl Sulfone, MW 1000
Cholesterol‑PEG‑Vinyl Sulfone (VS), MW 1000 (also called Cholesterol‑PEG1000‑VS) is an amphiphilic PEG‑lipid conjugate consisting of a hydrophobic cholesterol moiety, a hydrophilic PEG spacer of average molecular weight 1000 Da, and a reactive vinyl sulfone end group.
Core Properties
- Amphiphilicity: Cholesterol provides lipid solubility and membrane anchoring; PEG‑1000 imparts water solubility and steric stabilization.
- Reactivity: The vinyl sulfone group undergoes efficient, selective conjugation with thiol (‑SH) groups via thiol‑ene addition under mild conditions.
- Physical form: White to off‑white solid/powder.
- Solubility: Soluble in organic solvents (DMSO, DMF, DCM, chloroform) and dispersible in aqueous solutions.
- Storage: −20 °C, desiccated, protected from light.
Key Applications
- Drug delivery: Self‑assembles into micelles or liposomes to encapsulate hydrophobic drugs, improving solubility and prolonging in vivo circulation.
- Surface modification: Functionalizes lipid nanoparticles, liposomes, or surfaces for targeted delivery by conjugating to thiol‑containing ligands, peptides, or antibodies.
- Bioconjugation: Used in biopharmaceutical research for site‑specific coupling to proteins, enzymes, or other biomolecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
