Cbz-N-Amido-PEG5-CH2COOH
This product is a heterobifunctional PEG linker featuring a Cbz-protected amine, a PEG5 spacer, and a terminal carboxylic acid. The Cbz (carbobenzyloxy) group protects the amine for orthogonal deprotection, while the carboxyl group couples efficiently with primary amines or NHS esters to form stable amide bonds. The PEG5 chain specifically improves solubility, flexibility, and accessibility, making this reagent valuable for bioconjugation and drug delivery.
Key Features and Benefits
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Cbz-Protected Amine: Provides orthogonal protection for stepwise modification.
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Carboxyl Group: Couples with amines to form stable amide linkages.
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PEG5 Spacer: Enhances solubility and reduces steric hindrance.
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Versatile Design: Supports orthogonal conjugation strategies.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links biomolecules through protected amine and carboxyl groups.
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Drug Delivery: Serves as a modular PEG linker in therapeutic systems.
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Probe Development: Builds intermediates for multifunctional imaging probes.
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Polymer Science: Introduces PEG units into functional materials.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Remove Cbz under hydrogenolysis conditions; prepare carboxyl solutions fresh.
This product combines Cbz protection, PEG solubility, and carboxyl functionality in a medium-length scaffold, specifically offering a reliable tool for controlled conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
