Cbz-N-Amido-PEG8-acid
This product is a PEG8 linker with a Cbz-protected amide and a terminal carboxylic acid. The PEG8 spacer provides hydrophilicity, flexibility, and medium-length spacing, while the Cbz group offers stable carbamate protection for controlled, orthogonal conjugation strategies.
Key Features and Benefits:
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Cbz-Protected Amide: Stable carbamate protection, removable by hydrogenolysis.
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Carboxylic Acid Group: Couples efficiently with amines for amide bond formation.
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PEG8 Spacer: Provides balanced solubility and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Reactivity: Supports controlled and multistep synthetic strategies.
Applications:
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Bioconjugation: Enables precise protein, peptide, and biomolecule modification.
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Drug Delivery: PEGylated linker enhances solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
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Synthetic Chemistry: Serves as a protected intermediate for PEGylated scaffolds.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid stability.
This product combines medium PEG spacing with Cbz-protected functionality, making it an especially versatile tool for orthogonal synthesis, bioconjugation, and advanced material design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
