Cbz-N-Amido-PEG3-CH2COOH
This product is a PEG3 linker with a Cbz-protected amide and a terminal carboxymethyl group. The PEG3 spacer provides hydrophilicity and flexibility, while the Cbz group offers stable carbamate protection for controlled, orthogonal conjugation workflows.
Key Features and Benefits:
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Cbz-Protected Amide: Stable carbamate group, removable under hydrogenolysis.
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Carboxymethyl Group: Couples efficiently with amines to form stable amide bonds.
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PEG3 Spacer: Provides solubility and reduced steric hindrance with compact spacing.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Orthogonal Reactivity: Supports selective and stepwise conjugation strategies.
Applications:
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Bioconjugation: Enables precise biomolecule attachment with orthogonal protection.
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Drug Delivery: PEGylated linker improves solubility, pharmacokinetics, and stability.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels.
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Synthetic Chemistry: Useful intermediate for protected PEGylated scaffold design.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid integrity.
This product provides compact PEG spacing with stable protection, making it an especially versatile tool for orthogonal conjugation, drug delivery, and advanced synthetic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
