Cbz-N-Amido-PEG1-CH2COOH
This product is a compact PEG1 linker with a Cbz-protected amide and a terminal carboxymethyl group. The short PEG1 spacer provides limited hydrophilicity and spacing, while the Cbz group offers stable carbamate protection for orthogonal and stepwise conjugation strategies.
Key Features and Benefits:
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Cbz-Protected Amide: Stable carbamate protection, removable under hydrogenolysis.
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Carboxymethyl Group: Couples with amines to form stable amide bonds.
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PEG1 Spacer: Compact hydrophilic chain minimizes steric hindrance.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Orthogonal Reactivity: Supports controlled, selective, and multistep synthesis.
Applications:
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Bioconjugation: Compact PEG linker for protein, peptide, and biomolecule conjugation.
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Drug Delivery: Improves solubility and stability in PEGylated therapeutic systems.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
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Synthetic Chemistry: Serves as a protected intermediate in PEG-based scaffold design.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid stability.
This product offers compact PEG spacing with dual reactive groups, making it an especially versatile reagent for orthogonal synthesis, conjugation, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
