Butyne-DOTA-tris(t-butyl ester), CAS Number 2125661-54-1, is a specialized bioconjugation agent frequently used in radiolabeling and molecular imaging.
Overview
- Full Name: Butyne-DOTA-tris (tert-butyl ester).
- CAS Number: 2125661-54-1.
- Chemical Formula: C27H44N4O6.
- Molecular Weight: 520.67 g/mol.
Butyne-DOTA Applications
- Bioconjugation: The butyne group allows for click chemistry, enabling easy attachment to azide-functionalized molecules.
- Radiolabeling: DOTA serves as a strong chelator for metal ions, such as Gallium-68 for PET imaging or Yttrium-90 for targeted therapy.
- Imaging: It’s commonly used to create stable imaging agents for PET, SPECT, and MRI, enhancing diagnostic capabilities in biomedical research.
Properties
- Butyne Group: Facilitates click chemistry, a quick and reliable method for linking biomolecules.
- tert-Butyl Ester Protection: Protects DOTA’s carboxyl groups during synthesis, maintaining stability until deprotection for chelation.
- Chelating Strength: DOTA binds tightly to metal ions, ensuring stability in radiolabeled compounds.
Handling and Storage
- Storage: Keep in a cool, dry place, away from light to maintain stability.
- Handling: Use proper protective equipment to avoid unintended reactions during synthesis.
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