Bromoacetamide-PEG3-propargyl
This product is a high-purity heterobifunctional PEG linker featuring a bromoacetamide for thiol alkylation and a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The PEG3 spacer specifically improves solubility and flexibility for efficient bioconjugation.
Key Features and Benefits
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Bromoacetamide Group – Reacts selectively with thiols to form stable thioether bonds.
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Propargyl Group – Suitable for CuAAC click chemistry with azides.
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PEG3 Spacer – Enhances aqueous solubility and minimizes steric hindrance.
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High Purity – Ensures reproducibility in bioconjugation and chemical biology applications.
Applications
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Site-specific thiol labeling and modification
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Dual conjugation workflows combining thiol and azide click targets
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Protein, peptide, and antibody bioconjugation
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Surface and material functionalization
Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMSO, DMF). React bromoacetamide with thiols under mild conditions; use CuAAC click chemistry for alkyne–azide conjugation.
This product is a heterobifunctional PEG linker with a bromoacetamide for thiol alkylation and a propargyl group for CuAAC, joined by a PEG3 spacer specifically for solubility and flexibility in dual bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
