Boc-Val-Cit-PAB-PNP
This product is a cleavable ADC linker containing a Boc-protected Val-Cit dipeptide, a self-immolative PAB spacer, and a reactive para-nitrophenyl (PNP) ester. The Boc group provides stability and selective deprotection, while the PNP ester enables efficient coupling to amines, making this linker highly valuable in antibody–drug conjugate (ADC) synthesis.
Key Features and Benefits:
-
Boc-Protected Val-Cit: Stable, enzyme-cleavable dipeptide for targeted drug release.
-
PAB Spacer: Self-immolative unit ensures traceless payload release after cleavage.
-
PNP Ester Group: Highly reactive with amines for efficient conjugation.
-
Controlled Reactivity: Boc protection allows stepwise linker-payload assembly.
-
High Purity: Optimized for reproducible ADC and drug delivery workflows.
Applications:
-
Antibody–Drug Conjugates (ADCs): Core linker used in protease-cleavable payload release.
-
Drug Delivery Systems: Enhances stability, solubility, and controlled release.
-
Bioconjugation: Couples small molecules, drugs, or peptides via amine linkages.
-
Research and Development: Standard linker for testing in preclinical ADC models.
Storage and Handling:
-
Storage: Store at –20 °C, protected from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve PNP ester reactivity.
This product provides a gold-standard design specifically for cleavable ADC linkers, combining stability, orthogonal protection, and efficient conjugation chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
