Boc-Val-Cit-OH CAS:870487-08-4 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. The Boc group can be deprotected under acidic conditions to generate a free amine group.
Boc-Val-Cit-OH is a derivative of the amino acid valine, containing both a carboxylic acid functional group (-COOH) and a tert-butoxycarbonyl (Boc) protecting group. Additionally, it contains a citrulline moiety, which is another amino acid derivative that has been linked to various biological activities.
Boc-Val-Cit-OH is particularly valuable in drug discovery due to its ability to act as a building block for the synthesis of peptidomimetics, which are compounds that mimic the structural and functional properties of peptides. These peptidomimetics have proven to be a promising class of drugs, offering improved pharmacokinetic and pharmacodynamic profiles compared to their peptide counterparts.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
