Boc-HyNic-PEG3-Propargyl
This product is a heterobifunctional PEG3 linker with a Boc-protected HyNic group and a terminal propargyl (alkyne). The Boc-HyNic allows controlled deprotection for hydrazone chemistry, while the alkyne enables bioorthogonal click reactions with azides, making this linker versatile for multifunctional conjugation strategies.
Key Features and Benefits:
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Boc-Protected HyNic: Acid-labile protection for selective deprotection and hydrazone coupling.
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Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
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PEG3 Spacer: Enhances solubility, flexibility, and reduces steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Design: Combines hydrazone and click chemistry in one reagent.
Applications:
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Bioconjugation: Dual-functional linker for proteins, peptides, and biomolecules.
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Click Chemistry: Alkyne–azide ligation for bioorthogonal labeling.
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Drug Delivery: Useful in linker–payload strategies for targeted therapeutics.
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Surface Functionalization: Functionalize nanoparticles, hydrogels, and biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain reactivity and Boc integrity.
This product combines a protected hydrazone handle with click-ready alkyne functionality, making it an especially powerful tool for orthogonal and multifunctional conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.