Boc-HyNic-PEG3-Azide
This product is a heterobifunctional linker featuring a Boc-protected HyNic (hydrazinonicotinamide) group and a terminal azide. The PEG3 spacer enhances solubility and flexibility, making it especially effective for click chemistry, bioconjugation, and orthogonal probe or drug conjugate design.
Key Features and Benefits:
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Boc-Protected HyNic: Provides acid-labile orthogonal protection for stepwise synthesis.
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Azide Group: Enables CuAAC or SPAAC click chemistry with alkynes.
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PEG3 Spacer: Improves solubility, hydrophilicity, and steric accessibility.
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Orthogonal Reactivity: Supports multifunctional and modular conjugation strategies.
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High Purity: Ensures reliable results in sensitive workflows.
Applications:
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Bioconjugation: Links biomolecules with click-ready and protected handles.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal functional groups.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Synthetic Chemistry: Serves as an intermediate for modular linker design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature Boc cleavage.
This product combines HyNic protection with azide reactivity in a PEG3 scaffold, specifically offering solubility and orthogonal control for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
