Boc-HyNic-PEG1-Mal
This product is a heterobifunctional PEG1 linker featuring a Boc-protected hydrazinonicotinamide (HyNic) group and a maleimide for thiol conjugation. The short PEG1 spacer specifically provides compact hydrophilicity and flexibility, enabling efficient orthogonal conjugation strategies in bioconjugation and drug delivery.
Key Features and Benefits:
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Boc-Protected HyNic: Acid-labile protection allowing selective hydrazone coupling after deprotection.
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Maleimide Group: Reacts selectively with thiols for stable thioether linkage formation.
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PEG1 Spacer: Provides minimal spacing while enhancing solubility.
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High Purity: Ensures reproducibility in sensitive synthetic and biological workflows.
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Orthogonal Design: Combines hydrazone and thiol-based chemistries in one reagent.
Applications:
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Bioconjugation: Dual-functional linker for proteins, peptides, and antibodies.
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Drug Delivery: Facilitates orthogonal linker–payload assembly in targeted therapeutics.
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Click-Free Labeling: Maleimide–thiol reactivity supports site-specific conjugation.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected environment.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Boc and maleimide reactivity.
This product combines Boc-protected hydrazone chemistry with thiol-specific maleimide reactivity, making it an especially powerful dual-functional linker for controlled bioconjugation and drug delivery workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.