Boc-Gly-PEG3-endo-BCN
This product is a heterobifunctional linker combining a Boc-protected glycine group for orthogonal synthesis and an endo-bicyclononyne (endo-BCN) for copper-free SPAAC click chemistry. The PEG3 spacer specifically improves solubility and flexibility, making it valuable for bioorthogonal labeling, probe design, and multifunctional conjugation.
Key Features and Benefits:
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Boc-Protected Glycine: Provides controlled, acid-labile deprotection for stepwise synthesis.
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Endo-BCN Group: Supports rapid, copper-free SPAAC click chemistry with azides.
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PEG3 Spacer: Adds hydrophilicity, reduced steric hindrance, and compact spacing.
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Dual Functionality: Combines protected amine chemistry with orthogonal click reactivity.
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High Purity: Ensures reproducibility in bioconjugation and drug discovery workflows.
Applications:
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Bioorthogonal Labeling: Enables SPAAC ligation with azide-containing biomolecules.
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Bioconjugation: Supports dual-functional coupling strategies.
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Drug Delivery: PEGylated scaffold enhances solubility and stability of conjugates.
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Probe Development: Useful for imaging and targeted delivery applications.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to acids before deprotection.
This product provides orthogonal Boc chemistry with rapid click reactivity, making it an especially versatile tool for bioconjugation, probe synthesis, and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
