Boc-Gly-Gly-Phe-Gly-OH (CAS: 187794-49-6) is a tetrapeptide linker for ADCs and drug development. It includes a glycine-glycine-phenylalanine-glycine (GGFG) peptide sequence, a Boc-protected N-terminal amine, and a carboxyl (-OH) group at the C-terminus.
Key Features:
- Cleavable Linker: The GGFG sequence targets proteases for precise drug release.
- Boc-Protecting Group: Shields the amine during synthesis and removes easily under acidic conditions.
Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted cancer therapy.
- Bioconjugation: Connects biomolecules with enzyme-sensitive release.
- Drug Development: Builds enzyme-triggered prodrugs and therapeutic agents.
This linker supports precise drug delivery, enhancing therapeutic effectiveness and reducing side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
